Drug delivery surface erodibility

Anthony M. Lowman, Thomas D. Dziubla, Petr Bures, and Nicholas A. Peppas, Structural and Dynamic Response of Neutral and Intelligent Networks in Biomedical Environments F. Kurds Kasper and Antonios G. Mikos, Biomaterials and Gene Therapy Balaji Narasimhan and Matt J. Kipper, Surface-Erodible Biomaterials for Drug Delivery... 

In the early 1970s, the ALZA Corporation began its search for polymers suitable for erodible drug delivery systems. The ideal polymer was identified as one undergoing surface erosion in vivo and degrading to non-toxic, low molecular weight products at a rate that could be manipulated over a broad time span. To meet these criteria, a novel family of hydrolyzable polymers was developed, the poly(orthoesters), POEs [285]. The general structure is schematically shown in... 

Historically, polyanhydrides were developed in the textile industry during the first half of the 20th century as alternate fiber materials. " However, the modern polyanhydrides that are currently under investigation as drug delivery platforms represent a novel class of polymer that, unlike the polyesters, has been specifically developed for biodegradable applications. In particular, these polyanhydrides were specifically prepared in attempts to produce surface-eroding dosage forms. 

Narasimhan, B. Kipper, M.J. Surface-erodible biomaterials for drug delivery. Adv. Chem. Eng. 2004, 29, 169-218. 

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