Drug Carriers and Chelators

Besides effectively condensing DNA, PAIs can also form complexes with citrates and other multi-acidic molecules. As such, it is not a great leap to consider replacing the nucleic acids with simpler anionic drugs and to 

Cisplatin contains two nitrogen ligands, and as expected these can be replaced by polymeric amine units. When tetrachloroplatinum is stoi-chiometrically reacted with PEI it forms a water-insoluble eomplex, but if block copolymers are employed (such as PEO-PEI) then a water-soluble platinum-loaded micellar construct was obtained which showed greater cytotoxicity than cisplatin. 

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