Drug absorption slow gastric emptying

E. To be approved, generic formulations must exhibit the same rate and extent of absorption as the trademark compound. All of the other choices can affect drug absorption. For example, slowing gastric emptying time may increase the absorption of a... 

Both exenatide and liraglutide slow gastric emptying this may have an effect on the speed of absorption of other drugs (2) and partly contributes to nausea. 

All important pharmacokinetic parameters, such as drug absorption, volume of distribution, protein-protein binding, and drug metabolism must be taken into account when dose modifications are made in uremic patients. For example, gastroparesis in diabetic patients, slow gastric emptying time and edema of gastrointestinal tract in patients with advanced renal fail-... 

This study demonstrates that exenatide slows gastric emptying, and has the potential to delay the absorption of other drugs. The manufacturer recommends that exenatide should be used with caution in patients receiving oral drugs that require rapid gastrointestinal absorption. They do not give any specific examples. However, they do note that exenatide does not affect the absorption of lisinopril. 

DISOPYRAMIDE ANALGESICS Disopyramide may slow the onset of action of intermittent dose paracetamol These drugs have anticholinergic effects that include delayed gastric emptying. This will delay absorption Warn patients that the action of paracetamol may be delayed. This will not be the case when paracetamol is taken regularly... 

After oral administration, the swallowed drug rapidly reaches the stomach. Because the duodenum has the greatest capacity for the absorption of drugs from the GI tract, a delay in the gastric emptying time will slow the rate and possibly the extent of drug... 

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