Drivers for Performing the Menschutkin Reaction in Micro Reactors

1 Drivers for Performing the Menschutkin Reaction in Micro Reactors 

Most of the known organic reaction yield sooner or later precipitates or involves directly the addition of solid reagents [78]. Hence fouling phenomena are rather 

The Menschutkin reaction was carried out as a test reaction to show the feasibility of such novel micro flow concepts that allow to process fouling-sensitive reactions (see also Section 4.2.6 here another test reaction is decribed for the same purpose) [78]. The reaction of alkyl bromide with ternary bases such as pyridine or triethylamine gives quaternary salts insoluble in most solvents. Often, fairly rapid precipitation of this salt occurs, hence ideally serving as a test reaction for fouling sensitivity of micro-channel devices. The reaction of 4,4 -bipyridyl and ethyl bromoacetate [78] belongs to the category of fast-predpitating Menschutkin reactions, as the halide function is activated by the carbonyl fimction. 

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