Drivers for Performing Peptide Syntheses in Micro Reactors

1 Drivers for Performing Peptide Syntheses in Micro Reactors 

Dipeptides and longer peptides are typically synthesized by solid-phase chemistry at polymer beads, a route discovered by and named after Merrifield [5, 88]. Disadvantages of this approach are that the polymer support is expensive and additional steps for linkage to and cleavage from the polymer are required. Hence solution chemistries are an alternative to the Merrifield approach. 

Peptide synthesis from y9-amino acids is particularly attractive for first feasibility micro-reactor tests as there are no chiral centers which may complicate analysis of the products [5, 88]. y0-Peptides are also attractive owing to their stmctural and biological properties, especially concerning the stability versus degradation by peptidases as compared with their a-analogues (see original citations in [5]). 

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