Drivers for Performing Knorr Synthesis in Micro Reactors

1 Drivers for Performing Knorr Synthesis in Micro Reactors 

The Knorr synthesis was chosen as an example to demonstrate that with an automated micro-reactor system a further step was made over existing parallel micro flow processing techniques, providing a 2 x 2 library in a chip micro reactor [20]. The new approach was designed for much higher diversity, aiming at a 7 x 32 library. 

Hence the investigations made so far were aimed more at showing the capability of an automated micro-reactor system, using the Knorr synthesis as a model reaction however, to a certain extent, information on this synthesis itself was also gained (see Section 4.9.6.5) [20]. The Knorr synthesis of pyrazoles chosen is of industrial interest since by this route compounds with a wide range of biological activity can be produced. 

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