Drimanes antifeedant activity

Albicanol (66), a drimane-type sesquiterpene, was isolated from the liverworts Diplophyllum albicans [30] and also from the dorid nudbranch Cadlina luteomarginata [31] together with its acetate (67) which exhibits potent fish antifeedant activity. 

Abad A, Agulld C, Cunat AC, Gonzalez-Coloma A, Pardo D. Preparation of 9a-fluorinated sesquiterpenic drimanes and evaluation of their antifeedant activities. Eur. J. Org. Chem. 2010 2182 2198. 

Sesquiterpenoids possessing the drimane skeleton (22) exhibit an impressive series of biological properties. Recently, all aspects relative to occurrence [76], biological activity [76], insect antifeedant properties [77] and synthesis [78] of these terpenoids have been exhaustively reviewed. 

The diverse biological activity (e.g. insect antifeeding, plant growth regulation, molluscicidal) of a number of drimane sesquiterpenoids has stimulated considerable interest in their synthesis and the year under review has seen many new developments and improvements. Much of the synthetic work has centred around the key bicyclic diester (54) derived from 1-vinyl-2,6,6-trimethylcyclohexene and dimethyl acetylenedicarboxylate. In contrast to earlier results,34 Ley et al.8S... 

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