Drift of the Isotope Ratios During Peak Elution

2 Drift of the Isotope Ratios During Peak Elution 

Different hypotheses have been formulated to explain this drift, but none of them provides a dear explanation for this phenomenon. Below, the main suggestions are summarized. 

In the first studies related to the coupling of chromatography and MC-ICP-MS, it was assumed that this drift was due to isotope fractionation occurring inside the 

Other suggestions, such as the influence of the analyte concentration or the drift of the background, have also been excluded [11]. 

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