Doxycycline DRESS

Skin A 59-year-old woman of African origin took doxycycline as malarial prophylaxis for 3 weeks and developed a drug reaction with eosinophilia and systemic symptoms (DRESS), but patch tests with doxycycline were negative [60 ]. Her HLA phenotype was A3/A30 and B39/B42. 

Mailhol C, Tremeau-Martinage C, Paul C, Godel A, Lamant L, Giordano-Labadie F. Severe drug hypersensitivity reaction (DRESS syndrome) to doxycycline. Ann Dermatol Venereol 2010 137(1) 40-3. 

Skin Drug rash with eosinophilia and systemic symptoms (DRESS) is relatively common in patients taking minocycline, but seems to be much less so in patients taking doxycychne. However, a report has appeared in a 25-year-old woman of African origin who had been taking doxycycline for malaria prophylaxis for 3 weeks [122 ]. 

Adhirajan, N., Shanmugasundaram, N., Shanmuganathan, S., Babu, M. (2009) Collagen-based wound dressing for doxycycline delivery in-vivo evaluation in an infected excisional wound model in rats. Journal of Pharmacy and Pharmacology, 61,1617-1623. 

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