DOXP synthase

Inhibition of 1-deoxy-o-xylulose 5-phosphate synthase (DOXP synthase)... 

The first specific precursor for terpenoids in the cytoplasma is the Cg molecule mevalonic acid (MVA), which is built via the classical acetate/mevalonate pathway and converted by a series of phosphorylating and decarboxylation reactions into C5 isopentenyldiphosphate (IPP), the universal building block for chain elongation up to C20. In the chloroplasts, the biosynthesis of IPP starts from glyceraldehyde-3-phosphate and pyruvate to give l-deoxy-D-xylulose-5-phosphate (DOXP) via the non-mevalonate pathway as a recently detected alternative IPP route [19]. The reaction is catalyzed by the enzyme DOXP synthase and can be inhibited by a breakdown product of the herbicide clomazone [12]. 

FIGURE 523 The leaf isoprene formation at subcellular compartment level based on Reference [11].This figure illustrates the role of the cytosolic mevalonate and chloroplastic deoxyxylulose-5-phosphate (DOXP) pathways in the formation of dimethylallyl diphosphate (DMAPP), the precursor of isoprene by the isoprene synthase reaction. IPP, isopentenyl diphosphate HMG-CoA, 3-hydroxy-3-methylglutaryl-coen-zyme A MEP, 2-C-methyl-D-erythritol 4-phosphate PEP, phosphoenolpyruvate. (Adapted and reprinted with kind permission from Springer Science + Business Media [16], figure 1.)... 

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