Doxorubicin-Induced Glomerular Toxicity

Although doxorubicin and menadione ( 25 pM) generate extensive reactive oxygen species and decrease protein synthesis, there was no correlation between the extent of oxidative stress and cytotoxicity in isolated rat glomeruli exposed to 100 pM doxorubicin (Morgan et al. 1998). 

Di-2-ethylhexyl Phthalate-Induced Renal Microsomal P4J0 and b. Induction 

Phthalate esters are widely used as industrial solvents and plasticizers in the manufacture of different plastics. Di-2-ethylhexyl phthalate, the most commonly used phthalate ester in polyvinylchloride formulations, can constitute up to 40 % of the end product. (Autian 1973). Phthalate esters have been recognised as environmental pollutants (Overturf et al. 1979). Di-2-ethylhexyl phthalate is a representative of peroxisome proliferators in rodents, and also induces enzymes specific for other organelles, DNA synthesis and organ growth (Huber et al. 1996). 

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