Doxorubicin extravasation

If extravasation occurs, the infusion should be stopped immediately, with aspiration of fluid from the site, needle, and tubing as much as possible. The affected limb or area should be elevated (if possible). The site should be documented photographically as well as the time, date, site, patient complaints, and estimated volume of extravasated drug.36 Both hot and cold packs have been used to manage extravasations, but use of the proper therapy for certain agents is critical. For example, warm compresses have been shown to worsen doxorubicin extravasations, whereas cold packs may exacerbate vinca alkaloid... 

Anthracyclines Doxorubicin, epirubicin Myelosuppression, cardiomyopathy Alopecia, nausea, vomiting, stomatitis, ulceration necrosis with extravasation, red-colored urine, radiation-recall effect... 

Doxorubicin—monitor cumulative dose for cardiac toxicity (not to exceed 550 mg/M2 or 450 mg/M2 with prior chest radiotherapy) vesicant—avoid extravasation use 50% for bilirubin 1.5-3.0 use 25% for bilirubin > 3.0... 

Doxorubicin—monitor cumulative dose for cardiac toxicity (not to exceed 550 mg/M2) vesicant—avoid extravasation ... 

Doxorubicin - anthracycline antitumor antibiotic - DNA intercalating agent -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis) -cardiotoxicity (550 mg/M2) -vesicant if extravasated -rash and hyperpigmentation -alopecia (universal)... 

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