Doxorubicin Calcium-channel blockers

DOXORUBICIN CALCIUM CHANNEL BLOCKERS t serum concentrations and efficacy of doxorubicin when co administered with verapamil, nicardipine and possibly diltiazem and nifedipine however, no cases of doxorubicin toxicity have been reported Uncertain however, verapamil is known to inhibit intestinal P-gp, which may T bioavailability of doxorubicin Watch for symptoms/signs of toxicity (tachycardia, heart failure and hand-foot syndrome)... 

A reduction in the labeling yield of RBC has been reported for heparin, tin-over-load, aluminum, prazocin, methyldopa, hydralazine, digoxin, quinidine, jff-adrenergic blockers, (e.g., propanolol), calcium channel blockers (e.g., verapamil), nitrates (e.g., nitroglycerin), doxorubicin, iodinated contrast agents, and Teflon tubing (catheter) (Hladik et al. 1987). 

A4 Barbiturates, carbamazepine, corticosteroids, efavirenz, phenytoin, rifampin, troglitazone Antiarrhythmics, antidepressants, azole antifungals, benzc iazepines, calcium channel blockers, cyclosporine, delavirdine, doxorubicin, efavirenz, erythromycin, estrogens, HIV protease inhibitors, nefazodone, paclitaxel, proton pump inhibitors, HMG-CoA reductase inhibitors, rifabutin, rifampin, sildenafil, SSRIs, tamoxifen, trazodone, vinca anticancer agents... 

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