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Double-emulsion solvent removal method

To improve the oral bioavailability of calcitonin, Garcia-Fuentes et al. used tripalmitate nanoparticles coated with chi-tosan or polyethylene glycol. The nanoparticles were prepared by a double emulsion solvent evaporation method that was adapted due to its high efficiency for the encapsulation of peptides. The nanoparticles were stabilized with soybean lecithin and the surface coating was done by incubation of the prepared lipid nanoparticles in a chitosan/poloxamer solution or by initial addition of PEG-stearate to the organic phase. Excess stabilizers were removed by centrifugation. Whereas... [Pg.428]


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See also in sourсe #XX -- [ Pg.2320 ]




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