Double-blind crossover experiment

A double-blind, crossover study in 17 healthy subjects found that the inhalation of 40 mg of sodium cromoglicate had little or no effect on the performance of a number of tests on human perceptual, cognitive, and motor skills, whether taken alone or with alcohol 0.75 g/kg. Nor did it affect blood-alcohol levels. This is in line with the common experience of patients, and no special precautions seem to be necessary. 

Subjects and Loading of Oils. Six male volunteers (Table 2) were given orally the emulsified experimental oils (30 g lipid/m of body surface area) in the early morning after fasting for at least 12 h. The double-blind, crossover study was conducted in accordance with the principles of the Helsinki Declaration. All subjects gave their informed consent before starting this experiment. In the first examination, 3 of the men... 

In contrast, patients in the placebo arm of the double-blind continuation study done with venlafaxine had responded to placebo and then remained on placebo under double-blind conditions. Whereas a sizable percentage of the patients switched to placebo in the crossover studies likely required active drug treatment to experience a response, that is not necessarily true for placebo-treated patients in the double-blind continuation studies. Thus, the nature and the course of the illness in these two types of studies may not be the same, accounting for the difference in relapse rates. 

Zaleplon and zolpidem have been compared in two concurrent multicenter, randomized, double-blind, placebo-controlled crossover studies in chronic insomniacs (12). In study 1, zaleplon 10 mg, zolpidem 10 mg, or placebo were given double-bhnd to 36 healthy subjects under standardized conditions in a six-period, incomplete-block, crossover study (13). The subjects were gently awakened and given the medication at predetermined times, 5, 4, 3, or 2 hours before morning awakening, which occurred 8 hours after bedtime. When they awoke in the morning, subjective and objective assessments of residual effects of hypnotics were administered. There were no serious adverse experiences during the study all adverse events were mild to moderate. The most commonly reported adverse events associated with zaleplon were weakness and somnolence. Weakness, depersonalization, dizziness, and somnolence were the most frequent nervous system adverse events associated with zolpidem. 

In 1981, the results of a double-blind experiment with a crossover design were reported, with 9 multiple sclerosis (MS) patients given A -THC (5 or 10 mg) or placebo [ 198]. Relative to placebo, 10 mg of the drug significantly reduced spasticity as quantified by clinical and electromyographic measure-... 

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