Dosing routes

The expected outcomes of the patient depend on the specific drug, dose, route of administration, and reason for administration of an electrolyte but may include an... 

If PBPK models for endosulfan exist, the overall results and individual models are discussed in this section in terms of their use in risk assessment, tissue dosimetry, and dose, route, and species extrapolations. 

Species Dose (route) Half-Life (days)... 

Dose Route (iigikg) Time After Initial Injection (hr) Route Dose (liglkg) ... 

The overall results and individual PBPK models for trichloroethylene are discussed in this section in terms of their use in risk assessment, tissue dosimetry, and dose, route, and species extrapolations. Several PBPK models have been developed for inhaled trichloroethylene. In an early model by Fernandez et al. (1977), the human body was divided into three major compartments or tissue groups the vessel-rich group (VRG), muscle group (MG), and adipose tissue (fat) group (FG). The distribution of trichloroethylene in these... 

Given KK s presentation and history, create an appropriate VTE prophylaxis plan including the pharmacologic agent, dose, route and frequency of administration, duration of therapy, monitoring parameters, and patient education. 

Should BA be given vitamin K If yes, discuss the dose, route of administration, and an appropriate patient monitoring plan. 

What empiric antibiotic regimen would be a reasonable choice in this patient Provide a drug, dose, route, and frequency. 

Drug Dose Route Frequency Adverse Effects... 

Drug Dose Route Time to Effect ADRs Monitoring Counseling Points... 

Vaccine Common Abbreviation Dose Route Cautions... 

Absorption studies can be carried out using a variety of dosing routes, and although this chapter will focus on oral dosing, analogous stages can be envisioned after other methods of dosing. 

Name Starting Dose Route Frequency Dosage Forms c rc (J... 

Chlorpyrifos lethality to selected birds and mammals via single oral dose route of administration... 

Organism Dose, Route of Administration, and Other Variables Effects Ref.a... 

Table 14.5 Chlorpyrifos Lethality to Selected Birds and Mammals via Single Oral Dose Route of Administration (Values are in mg chlorpyrifos/kg body weight lethal to 50% within 14 days.)...

Regimen Standard Dose Low Dose Route Frequency... 

Intended manner of use, including dose, route of administration and particulars of dosing regimen. 

Common Dosing Techniques. Dosing routes and permissible volumes for nonhuman primates vary between laboratories. The volume limitations from one laboratory are presented in Table 16.12. 

Primates offer all of the possible dosing routes available in humans, but body size often limits dosing volumes. If volumes for subcutaneous or intramuscular injections exceed those suggested above, enzyme elevations [particularly alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] are frequently observed (unpublished results). Continuous infusion techniques in alert animals are available in some laboratories either through use of programmable backpack pumps or jacket-and-tether systems (Perkin and Stejskal, 1994). 

Kenyon EM, Seeley ME, Janszen D, et al. 1995. Dose-, route-, and sex-dependent urinary excretion of phenol metabolites in B6C3F, mice. J Toxicol Environ Health 44 219-233. 

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