Dose-damage relationship

Dose-damage relationships and intergranular fracture in irradiated submerged-arc welds (SAWs)... 

Mechanistic framework to develop dose-damage relationships (DDRs)... 

We have seen that many different factors can contribute to chemical hazard in the workplace. The degree of hazard, however, is fundamentally determined by two factors the basic toxicity of the agent concerned, that is, its intrinsic capacity to damage or affect biological tissue and the severity of the exposure, or what is sometimes called the dose-response relationship. The duration of the exposure, of course, must also be considered. 

All compounds used had equivalent purity (see Table 11). The test design was focused on the evaluation of histological differences after a tamponade time of 6 weeks. The density of the PFCLs used was 1.32 g/ml (perfluorobutylbutane), 1.62 g/ml (perfluorohexyl-ethane) and 1.78 g/ml (PFO). There was no dose-response relationship that means there is no evidence that a higher density creates more severe histological damage. Therefore, the simple explanation of the insufficient long-term tolerance for PFCLs could not be verified. 

Kitchin KT, Brown JL. 1994. Dose-response relationship for rat liver DNA damage caused by 49 rodent carcinogens. Toxicology 88 31-49. 

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