Dosage, problems with determining

Specificity is the ability to assess unequivocally the analyte in the presence of components that may be expected to be present. A major problem with utilizing NIR to accurately determine concentrations of actives in solid dosage forms is that... 

Clients with bipolar disorders cannot be helped until they have been thoroughly assessed for appropriate medication. Once the need for medication is determined, the goal is to identify the appropriate medication and dosage. Clients with bipolar disorder, and for Aat matter any client with a serious psychiatric illness, should not be prescribed medication as the sole treatment intervention. Although major advances have been made in the field of psychotropic medication, clinical practice and the literature have always emphasized the multifaceted approach for multidimensional problems. It is important to remember that all mental illnesses impact on the biological, social, and psychological spheres of a client s life and functioning (Walsh, 1989). 

The course of post-LSD pupillary changes, with respect to dosage schedule and intensity and duration of effects, is a valuable tool. Pupil size 3 hr after the initial dose responded to the second dose of LSD and was an obvious measure to track in acute tolerance studies in humans. Given the number of rat studies in which this would be useful to monitor, the problem lies in determining rat mydriasis (easy in other animals) while a computerized pupillometer (developed by Martin Adler at Temple University) was informally tried by us once with LSD, systematic studies have not been done. 

The drug-excipient compatibility screening model developed by Serajuddin et al. [25] could be used to determine potential stability problems due to interactions of API with excipients in solid dosage forms. Table 15-4 shows an example of binary and ternary mixtures employed by Serajuddin et al. 

Matrix-sustained release tablets may present additional problems since they tend to stick to the side walls of the vessel, giving a reduction in the surface area exposed and the use of the paddle may destroy the discreteness of the dosage form. In such instances, the choice of apparatus is critical. Osmotic pump devices where a microscopic orifice is laser-drilled into the surface of the tablet coating are not amenable to testing by Apparatus 1-4 as the tablet may lie in such an orientation as to obscure the hole. In this case, drug release is determined by USP Apparatus 7 with the tablet glued onto the end of a reciprocating rod. 

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