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Dosage factors, toxicity testing

The answer is 3 [Chapter 8 III A 21. Type II (idiosyncratic, unpredictable, drug-related) hepatotoxicosis is probably caused by irxlivkl-ual differences in the ability to metabolize atx) detoxify xenobiotics. These diflierences may be hereditary arxl are txrt detected by routine experimoilal toxicity testing. Thus, excessive suscepfibilHy tttay occur at very low dosages arx] a dose-response relationship is rxrt demonstrable. Prior sensitization (e.g., by an allergic-type reaction) may also be a factor. [Pg.458]

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See also in sourсe #XX -- [ Pg.4 , Pg.5 ]



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