Domino hydroformylation-Wittig olefination

For domino hydroformylation/Wittig olefinations see a) B. Beeit, S. K. Zahn, Angew. Chem. 1999, 111, 1022-1024 Angew. Chem. Int. Ed. Engl. 

Scheme IS. Domino hydroformylation-Wittig olefination. Reagents and conditions 1.1 Equiv.

Rhodium-catalyzed hydroformylation of terminal alkenes in the presence of stabilized phosphorus yhdes was found to initiate a domino hydroformylation-Wittig olefination process. When monosuhstituted acceptor-stabilized phosphorus ylides were employed, a hydrogenation step follows the Wittig olefination to give a domino hydroformylation-Wittig olefination hydrogenation process (Equation 7.19) [166]. 

A reaction in agreement with these efficiency criteria would be a domino stereoselective-hydroformylation-Wittig olefination process. This would require that the hydroformylation reaction be compatible with the presence of a Wittig ylid throughout the course of the reaction. 

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