Domino Diels-Alder/Prins/Pinacol reaction

Quite recently, a domino Diels-Alder/Prins/pinacol reaction was reported by Barriaulfs group [38]. This novel method is very reliable and efficient for the synthesis of highly functionalized bicyclo[m.n.l]alkanones. In addition, Aube and coworker [39] used a combination of a Diels-Alder and a Schmidt reaction within the total synthesis of the Stemona alkaloid stenine [40]. 

Domino Diels-Alder/Prins/Pinacol Reactions... 

Barriault et al. demonstrated the Lewis acid-mediated triple domino Diels-Alder/ Prins/Pinacol reactions [22], which were utilized for the construction of highly functionalized bicyclo[m.n.l]alkanones [23]. Some tetra-fused carbocycles were efficiently produced from the corresponding cycloadducts generated in situ by the Diels-Alder reaction of 2,2-dimethyl-1,3-dioxolanes having a diene moiety at C4 position with dienophiles (Scheme 10.6). 

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See also in sourсe #XX -- [ ]

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