Domino/cascade catalysis

Furthermore, Fogg and dos Santos categorized the different types of mnlticatalyzed one-pot reactions in 2004 [25], some years after Tietze set the definition of domino reactions [12]. In this categorization, domino/cascade catalysis, tandem catalysis, and multicatalytic one-pot reactions were distinguished depending on certain factors, snch as the moment when the (pre)catalysts are added and the number... 

Nature accomplishes many syntheses-even those of complex molecules-by sequences of elementary steps. In the last few decades, the blueprint of catalyzed cascade reactions has found fertile soil through the advent of transition metal catalysis in laboratories. Scrutinizing catalytic cycles and mechanistic insight has paved the way for designing new sequential transformations catalyzed by transition metal complexes in a consecutive or domino fashion. In particular, transition metal-catalyzed sequences considerably enhance structural complexity by multiple iterations of organometalhc elementary steps. All this has fundamentally revolutionized synthetic strategies and conceptual thinking. 

In 2011, Panteleev et al. reported a domino alkyne arylation and N-arylation process by combining rhodium and palladium catalysis [10], Based on a Rh-catalyzed alkyne arylation and subsequent Pd-catalyzed intramolecular N-arylation process, this multicatalytic cascade reaction efficiently incorporated amine-pendant aryl alkynes 25 and aryl boronic acid into functionalized dihydroquinoline derivatives (Scheme 9.7). 

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