Dohme, Charles

Brown, H. D., Marianne Costlow, Frank A. Cutler, Albert N. DeMott, Walter B. Gall, David P. Jacobus, and Charles J. Miller, "The Computer-Based Chemical Structure Information System of Merck, Sharp and Dohme Research Laboratories," Journal of Chemical Information and Computer Sciences, 16(1), 5-10 (1976). 

However, despite these and other early observations, it was not until considerably later that Cushny demonstrated clearly that one enantiomer of a molecule could be much more active pharmacologically than the other enantiomer [23], Thus ( — )-hyoscyamine was 12-20 times as active as the (+ )-enantiomer with respect to their action on motor nerve endings. In his Charles E. Dohme Memorial Lecture (1925), Cushny [23] stated with reference to optical activity The chemists have long been mildly interested in this form of vital activity, the pharmacologists have shown its importance in their sphere, but biologists in general do not seem to have appreciated it as a very definite and measurable feature of living matter . 

M. Katharine Holloway (Merck Sharp and Dohme, West Point), Kenneth M. Merz (University of California, San Francisco), and Charles H. Reynolds (Rohm and Haas)... 

I would like to express my appreciation to Loretta A. McQuaid, Paul M. Chouinard, Charles R. Johnson, and Robert T. Lum, who carried out the research described above. We would like to thank Professor Jeremy R. Knowles for providing us with purified chorismate mutase-prephenate dehydrogenase used in the studies described in Tables 2 and 3 as well as an authentic sample of shikimate-3-phosphate. The financial support of Merck Sharp Dohme, as well as the National Institutes of Health (grant no. GM-28965), is also gratefully acknowledged. 

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