Doehlert design sequentiality

Fig. 6.16. Doehlert design for Ivvo factors (points / till 7) and demonstration of the sequentiality of the design (additional points 8-10).

FIGURE 2.7. Doehlert design for two factors (at least seven experiments). Dotted line possibility for sequentially moving the design in the direction of the arrow by executing three additional experiments. 

We will now look at the practical use of the Doehlert design, demonstrating its various properties of sequentiality. 

Sequential approach using the Doehlert design wet pelletization in a high-shear mixer... 

Cadmium is sometimes determined together with other metals such as zinc, lead, and mercury. Generally, these applications are based on the formation of metal-ligand complexes, and some kinds of statistical or chemometric tools (full factorial designs, sequential experimental Doehlert designs, artificial neural network, partial least square) are used for distinguishing the concentrations of each analyte. In addition, some applications are based on the kinetic differentiation of the reactions related to metals and the same ligands. 

FIGURE 15 Sequentiality of a Doehlert Design with two variables. 

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