Dodecylpyridinium halide

An electrode selectively responsive to an ionic ligand in equilibrium with ligands bound on a macromolecule can be utilized to construct binding isotherms.21 23,35 Dodecylpyridinium halide was chosen in this work as an amphiphilic ligand because an excellent electrode sensitive to it was found. This amphiphile is regarded as a model compound of many classes of biomedical molecules since it combines hydrophobic, aromatic, and polar (cationic) groups. The limited number of papers published on DNA-surfactant interaction,36 further prompted this work. 

Interaction between calf thymus DNA and dodecylpyridinium halide (DoPX) was studied through binding isotherms, varying concentrations of added sodium chloride, and temperature. The results are ana ed in term of a one-dimensional nearest neighbor interaction model. The... 

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