Dodecanoyl chitosan

In Table 2, the amounts of the freezable and nonfreezable water are given. For the chitosan gel itself, the higher the amino content, the lower the amounts of the freezable water. The introduction of an octanoyl group (D.S. = 0.3-0.4) leads to the increase of the freezable water. Further increase of the degree of substitution over 0.6 gives a decrease and finally reaches zero at D.S. = 1.0. On the other hand, in the case of dodecanoyl chitosan, the amounts of freezable water decrease linearly with increasing D.S. In the introduction of a benzoyl group, the amounts of the freezable water increases at D.S. = 0.3 and then decreases to the... 

A variety of acylation reactions of chitosan are possible by using different acyl-ating agents, such as aliphatic carboxylic acid chlorides (hexanoyl, dodecanoyl and tetradecanoyl chlorides), cyclic anhydrides and cyclic esters. The acylation reaction is not regioselective. When IV,0-acylated chitosans were prepared with acyl chlorides in methanesulfonic acid [62-63], the derivatives of 4-chlorobutyl and decanoyl chlorides showed higher fungidal activities than chitosan [64]. Selectively N-acylated chitosan have been obtained by Lee et al. [65-66] with butanoic, hexanoic and benzoic anhydride under homogeneous conditions... 

Grant, S., Blair, H. S., and Mckay, G. 1990. Deacetylation effects on the dodecanoyl snbstitution of chitosan. Polym Commun. 31 267. 

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