Docosahexaenoic acid oxidative stability

An interesting example which capitalizes on the ability of the hydro-phobic cavity of (3-lactoglobulin to carry a hydrophobic molecules and complexation has been recently reported (Zimet and Livney, 2009). It was found that (S-lactoglobulin binds docosahexaenoic acid (DHA) and further that DHA-loaded (S-lactoglobulin can form nanocomplexes ( 100 nm) with low methoxy pectin at a pH colloidal stability and protected DHA against oxidation. 

FA distribution in TAG as well as in phospholipids affects the physical properties, lipolitic and oxidative stability, and nutritional availability of lipids. In many TAG, the FA are arranged in a nonrandom distribution. In plants, monoenoic FA and PUFA are dominant at a sn-2 position (Orthoefer, 1996). In pig depot fat and in cow s milk, the TAG sn-2 position is occupied by palmitic acid. The distribution is also different in cattle and sheep depot fats (Love, 1996). In blubber seals, long-chain n-3 PUFA are esterified rather in sn-l,3 positions, whereas, in muscle, TAG in the sn-2 position that is typical for the lipid muscles of nearly all fish (Ackman, 1994). Enzymatic syntheses of structured TAG containing dY-5,8,ll,14,17-eicosapentaenoic acid (EPA) and dY-4,7,10,13,16,19-docosahexaenoic acid (DHA) in the sn-2 position with medium-chain FA at the end positions are particularly interesting (Halldorsson... 

Production of TAG enriched with polyunsaturated fatty acids (PUFA) via lipase catalysis in codliver oil has also been described (Haraldsson et ah, 1989). Preparation of y-linolenic acid enriched TAG via rapeseed lipases (Syed Rahmatullah et aL, 1994 Jachmanian and Mukerjee, 1996) and microbial lipases (Akoh et aL, 1995, 1996) has also been reported. Incorporation of eicosapentaenoic and docosahexaenoic acids into peanut oil via transesterification catalysed by microbial lipases has been reported by Sridhar and Lakshminarayana (1992). According to Wada and Koizumi (1986) and Kimoto et aL (1994) interesterification of fish oils to form TAG containing PUFA in the 2-position rather than the 1,3-positions increases the oxidative stability of the modified oil as compared to its original counterpart. 

Vikbjerg AF, Andresen TL, Jorgensen K et al (2007) Oxidative stability of liposomes composed of docosahexaenoic acid-containing phospholipids. J Am Oil Soc 84 631-637... 

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