Dock domain

Hancock CN, Macias A, Lee EK, Yu SY, Mackerell AD Jr, Shapiro P. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J. Med. Chem. 2005 48 4586-4595. 

C-terminai docking domain mediates inter-polypeptide communication... 

Figure 2 Conventional modular type I PKS paradigm, (a) Individual domains in a full type I polyketide synthase extension module. Homodimeric contacts are made in the N-terminal docking, ketosynthase, dehydratase, enoyi reductase, and C-terminal docking domains, (b) PKS system for 10-deoxymethynolide and narbonolide generation.

Substrate recognition and selection of the JNK/SAPK and p38 proteins (and also the ERK proteins) are mediated both by specific docking sites and by the nature of the amino acids surrounding the phosphoacceptor site. For the transcription factor substrates, specific docking domains have been identified that are loacted at a distance from the phosphorylation sites in the transactivation domain. These docking sites serve to increase the selectivity and specificity of phosphorylation, and they are used for recruitment of MAPK kinases into protein complexes at promotors, where they can phosphorylate other regulatory transcriptional proteins. 

K. Weissman, The structure of docking domains in modular polyketide synthases, Chem. Biol. 2003, 10, 723-731,... 

Li X, Chen H, LJungdahl L (1997) Two cellulases, CelA and CelC, from the polycentric anaerobic fungus Orpinomyces strain PC-2 contain N-terminal docking domains for a cellulase-hemicellulase complex. Appl Environ Microbiol 63 4721-4728... 

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