Erythema docetaxel

Of 99 patients who received low-dose docetaxel (60 mg/m every 3 or 4 weeks), 25 had skin toxicity, mainly erythema and nail changes (7). Of a subset of 25 patients who received irradiation before docetaxel, four had recall dermatitis during their first infusion of docetaxel. AH had previously received doxorubicin, which may in part have explained some of the toxicity. 

Docetaxel Taxane (Diterpene) Breast, prostate, ovarian, nonsmall cell lung Inhibition mitotic cell-division Acral erythema scleroderma-Uke Neutropenia anemia Dys Br GI symptoms Cross-reaction with paclit el but reactions less frequent Infusion... 

A recent multi-institution survey in Japan drew attention to an important effect of histamine H2 antagonists on docetaxel-induced skin toxicity. Analyses revealed that administration of H2 blockers was associated with a significantly higher incidence of acral erythema (hand-foot syndrome palmar-plantar erythrodysesthesia compare with hand-foot skin reaction. Sects. 13.3.2 and 13.3.3 and see Fig. 13.1) and facial erythema. Steroids and H2 blockers affect the metabolism of docetaxel by cytochrome P45o3A4 (CYP3A4), but dexamethasone dosage did not change the incidence of hand-foot syndrome or facial edema. 

Immunologic Hypersensitivity reactions to docetaxel occur in about 20-30% of cases, usually within a few minutes of starting an infusion [142 ]. They most commonly occur during the first or second cycle of treatment. The symptoms may be minor, such as flushing or localized cutaneous reactions, or more severe, such as severe hypotension, bronchospasm, or generalized rash/ erythema. Patients who develop severe hypersensitivity reactions should not be rechallenged with docetaxel [111 ]. 

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