DNA sequencing technologies

The advances in protein, and especially DNA, sequencing technology means that there is now a vast amount of primary structural information relating to biological macromolecules and it is hence essential for laboratories in the field to make use of computers to analyse data on protein and nucleic acid sequences. At present (June 1994) there are more than 80000 sequences in the OWL protein sequence database [8] and there are more than 170000 nucleic acid sequences in the EMBL (European Molecular Biology Laboratory) database [9]. 

Traditional diagnostic methods for clinical analysis based on coupling of electrophoretic separations, radioisotope or fluorescent labeling are toxic and time consuming. Due to these labor-intensive methods these are not well suited for routine and rapid clinical analysis [2]. Recently, there have been major advances in DNA sequencing technologies [3]. Several methods including various... 

Universal nucleic base analogues and their applications in DNA sequencing technology 13RCA14910. 

Table 1 Websites providing insights into different aspects of novel DNA sequencing technologies ...

Moorthie S, Mattocks Cl, Wright CF (2011) Review of massively parallel DNA sequencing technologies. HUGO J 5 1-12... 

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