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DNA ligase mechanism

DNA ligase, whose reaction is reversible, is able to relax supercoiled circular DNA in the presence of AMP but not in its absence. Outline the chemical mechanism of the ligase reaction. Why is it dependent on AMP What other DNA ligase mechanism is known ... [Pg.1601]

Figure 27.29. DNA Ligase Mechanism. DNA ligation proceeds by the transfer of an AMP unit first to a lysine side chain on DNA ligase and then to the 5 -phosphate group of the substrate. The AMP unit is released on formation of the phosphodiester linkage in DNA. Figure 27.29. DNA Ligase Mechanism. DNA ligation proceeds by the transfer of an AMP unit first to a lysine side chain on DNA ligase and then to the 5 -phosphate group of the substrate. The AMP unit is released on formation of the phosphodiester linkage in DNA.
See also in sourсe #XX -- [ Pg.113 , Pg.115 ]



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