DNA Hybridization Assays on Chip

Microfluidic DNA hybridization assays Nucleic acid hybridization assays On-chip DNA hybridization analysis... 

The basic idea of on-chip DNA hybridization assays is to integrate assay operations such as sequential sample loading, transportation, mixing, incubation, and detection on a single microfluidic chip. Although the microfluidics-based DNA hybridization assays share the same basic principle, the formats of these assays vary. Generally, the present-day formats of the on-chip DNA hybridization assays remain the main types directed liquid flow-based on-chip DNA hybridization assays, surface-based on-chip DNA hybridization assays, bead-based on-chip DNA hybridization assays, and the on-chip DNA hybridization assays with membrane/film-based transducer. 

Directed Liquid Fiow-Based On-Chip DNA Hybridization Assays... 

Several research efforts on directed liquid flow-based on-chip DNA hybridization assays have been reported. 

Weng X, Jiang H, Wang J, Chen S, Cao H, Li D (2012) Automatic on-chip RNA-DNA hybridization assay with integrated phase change microvalves. J Micromech Microeng 22 075003... 

Hybridization on integrated Au chip, light detection with a PIN photodiode detector, assay was based on displacement of DNA hybridization, ECL in phosphate buffer (pH 8.0)-0.10 TPrA... 

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