DNA Binding of Polynuclear Platinum Complexes

Compound (pM) In VIVO (L1210/CDDP onlyp In vivo LX-I  

Cooperative Effects in the Solution Structures of Site-specific (Pt,Pt) Interstrand Cross-links 

A logical place, therefore, to begin to examine for the structural origin of differential effects between mononuclear and polynuclear platinum complexes is in the structures of interstrand cross-links. Interstrand cross-linking of poly(dG-dC).poly(dG-dC) by cw-DDP does not cause a B - Z transition. The inter- 

It is a great pleasure for the authors to acknowledge the dedication and enthusiasm of all the team in Boehringer Mannheim for this project. We wish to also thank V. Brabec and F. Zunino for their valuable cooperation and insight. 

Manzotti, D. Torriani, E. Randisi, M. De Giorgi, G. Pezzoni, E. Menta, S. Spinelli, H.H. Fiebig, N. Farrell and F.C. Giuliani, Proc. AACR, 1997,38,2080. 

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