DNA, as a target

Kerwin SM. 2000. G-Quadruplex DNA as a target for drug design. Curr. Pharm. Des. 6 441-78... 

LAWLEY, P.D. (1980) DNA as a target of alkylating carcinogens. In Chemical Carcinogenesis, edited by P.Brookes, British Medical Bulletin, 36, 19. 

Palchaudhuri R, Hergenrother PJ (2007) DNA as a target for anticancer compounds methods to determine the mode of binding and the mechanism of action. Curr Opin Biotechnol 18 497-503... 

In the case of platinum complexes many gross biological effects have been attributed to nucleic acid interaction and since the vast majority of mechanistic work predicates the role of DNA as a target it is useful to summarize these data here. 

Complementary DNA as a target Yellow or green fluorescence should be observed in the FITC filter (yellow fluorescence can be visible due to the presence of Cy3 label on the complementary DNA target) red fluorescence should be visible in the Texas Red filter... 

RNA is as suitable (if not more so) than DNA as a cleavage target [37]. In contrast to DNA, RNA is substantially less prone to oxidative cleavage [38] as a consequence of the higher stability of the glycosidic bond in ribonucleotides compared to that in deoxyribonucleotides. On the basis of the properties described in the introductory sections RNA is by contrast, much less stable to hydrolytic cleavage. For this reason the hydrolysis of the phosphate bond in this system can be successfully catalyzed not only by metal ions but also by ammonium ions. 

Duck hepatitis B virus (DHBV) has been proposed as a possible model for the inactivation of human HBV by chemical disinfectants. The principle of the test method uses viral DNA polymerase (DNAP) as a target, total inhibition in vitro of DNAP by chemical disinfectants being predictive of inactivation of infectivity in vivo. 

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