DKR-Related Methods

An enantiomer-selective reaction accompanied by in situ stereoinversion of the racemic substrate generates a non-racemic product Theoretically, this process can give 100% yield without repetition of sequential processes, such as separation of the slow-reacting enantiomer, racemization and KR. Over the past decade, the number of examples utilizing DKR has increased due to the use of a variety of racemization techniques. The efficiency of these processes can be evaluated by analysing kfjkg, 

Faber has classified strategies other than DKR into six different patterns [5] 

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DKR-related methods are outlined by selecting one example from each category. For simplicity, reactions involving a mixture of equihbrating diastereoisomers with an achiral reagent have been excluded. An excellent analysis of these reaction types has been included in the reviews written by Ward [4b] and Pellissier [4h-j], whereas DKR of oxazolidinones and imidazolidinones has been reviewed by Santos et al. [6j. 

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