DKR by Atroposelective Cleavage of a Bridge

In 2008, Ashizawa and Yamada developed asymmetric atroposelective ringopening of biaryl lactones with methanol catalysed by AgBp4 combined with a 

The two-fold hydride addition to biaryl-thionolactone complexes followed by decomplexation of the generated ruthenium thiolates yielded the 

3 Application of the Lactone Concept to Configurationally Unstable Compounds other than Biaryl Lactones 

The first catalytic atropoenantioselective addition of a C-nucleophile such as diethylzinc in the presence of 10 mol % of (-)-DBNE to biaryl hydroxy aldehydes was reported by Bringmann et al, providing the corresponding secondary alcohols, albeit in low diastereoselectivity and moderate enantio- 

The last fifteen years have seen families of atropisomers based on structures other than biaryls come forward as potential new sources of such structures, and atropisomeric anilides, benzamides and naphthamides have been used as chiral ligands, catalysts, auxiliaries and various starting materials. A number of 

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