Combinatorial series

Agrafiotis D K, J C Myslik and F R Salemme 1999. Advcinces in Diversity Profiling and Combinatorial Series Design. Molecular Diversity 4 1-22. 

Agrafiotis DK, Myslik JC, Salemme FR. Advances in diversity profiling and combinatorial series design. Mol Div 1999 4 1-22. 

Agrafiotis, D. K., Myslik, J. C., and Salemme, F. R. (1999) Advances in diversity profiling and combinatorial series design. Annu. Rep. Comp. Chem. Mol. Diversity 2, 71-92. 

Figure 7. Generalized scheme for the interplay between a structure-based series and a combinatorial series of lead drug compounds...

Advances in diversity profiling and combinatorial series design... 

Substructure searches provide another method of searching for available starting materials. They arc used primarily for planning the synthesis of combinatorial libraries. After the target compound has been dissected into a set of suitable precursors, substructure searches can provide for each of them a series of representatives of a certain class of compounds, Siibsti ucturc searches enable the user to specify attributes such as open sites or atom lists at certain positions of the structure. Figure 10.3-38 shows the possible specification elements for the query in a substructure search. 

The combinatorial interpretation (or the computations of Sec. 14 regardless of combinatorial considerations) implies the following useful result Substituting a power series with non-negative integer coefficients in the difference of the cycle indices of A, and we get a power series with non-negative integer coefficients. 

The hexahydro-2-methyl-477-[l,4]oxazino[3,4-3][l,3]oxazin 4-one 393 was prepared in excellent yield by electrochemical oxidation and cyclization of the 3-hydroxy-l-(morpholin 4-yl)butanone 392 (Equation 44). The oxazino[3,4+][l,3]oxazin-4-one 393 is one of a series of compounds obtained by utilization of electrochemistry in parallel and combinatorial syntheses <2000JC0545>. 

Cook, W., Cunningham, W., Pulley-blank, W. and Schrijver, A. (1998) Combinatorial Optimization. Wiley-Interscience Series in Discrete Mathematics and Optimization, Wiley, New York. 

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