Diuretics mental effects

Diuretics are not a psychoactive drug and have no direct mental effects. However, abuse and misuse of this medication can lead to severe dehydration, which may lead to headaches and mental confusion. 

Individuals on long-term diuretic therapy may also experience elevated levels of homocysteine, an amino acid regulated by folate. High homocysteine levels increase the risk of heart disease. Thiamin, or vitamin Bj, depletion is another possible side effect of loop diuretics. Individuals with thiamin deficiencies are at risk for fatigue, heart enlargement, muscle cramps, heart rate irregularities, and impaired mental function. 

Diuretics and alcohol increase the hypotensive action of methyldopa (37 ). Ox-prenolol too is said to augment the hypotensive action, rendering it possible to reduce methyldopa dosage and thereby lowering the incidence of side effects (54< ). Interaction between methyldopa and haloperidol, both of which affect dopamine in the CNS, was found to result in an acute dementia in 2 patients who received the drugs simultaneously. The condition was reversible, and the mental condition was again normal 3 days after withdrawal of the haloperidol (148 ). 

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