Carbonic anhydrase inhibitor diuretics

Thiazide and related diuretics, loop diuretics, potassium-sparing diuretics, carbonic anhydrase inhibitors, triamterene Avoid exposure to sunlight or ultraviolet light (sunlamps, tanning beds) because exposure may cause exaggerated sunburn (photosensitivity reaction). Wear sunscreen and protective clothing until tolerance is determined. 

Hypersensitivity to sulfonamides or chemically related drugs (eg, sulfonylureas, thiazide and loop diuretics, carbonic anhydrase inhibitors, sunscreens with PABA, local anesthetics) pregnancy at term lactation infants less than 2 months of age (except in congenital toxoplasmosis as adjunct with pyrimethamine) porphyria salicylate hypersensitivity. 

It is noteworthy that sulfanilamide structural modifications have led to other valuable classes of drugs already discussed, including the hypoglycemic sulfonylureas and the diuretic carbonic anhydrase inhibitors. 

Other drugs, such as verapamil, caffeine, theophylline, osmotic diuretics, carbonic anhydrase inhibitors, or aminophylline, can increase lithium excretion, possibly dropping plasma levels below the therapeutic threshold ( 329). Further, if doses are increased to compensate for this effect, care must be taken to readjust the lithium downward when these concomitant agents are reduced or discontinued. 

Diuretics John P Howe Introduction Classification Osmotic diuretics Carbonic anhydrase inhibitors Loop diuretics inhibitors of Na+/K+/2CI- transport Thiazide diuretics... 

DISOPYRAMIDE DIURETICS-CARBONIC ANHYDRASE INHIBITORS, LOOP DIURETICS, THIAZIDES Risk oft myocardial depression Cardiac toxicity directly related to hypokalaemia Monitor potassium levels closely... 

SOTALOL DIURETICS-CARBONIC ANHYDRASE INHIBITORS, LOOP DIURETICS, THIAZIDES t risk of ventricular arrhythmias, particularly torsades de pointes ventricular tachycardia, caused by sotalol Hypokalaemia, a side-effect of these diuretics, predisposes to arrhythmias during sotalol therapy Normalize potassium levels before starting sotalol in patients already taking these diuretics. When starting these diuretics in patients already taking sotalol, monitor potassium levels eveiy 4-6 weeks until stable... 

CARDIOVASCULAR DRUGS DIURETICS Carbonic anhydrase inhibitors... 

MEMANTINE DIURETICS-CARBONIC ANHYDRASE INHIBITORS Possible t memantine levels 1 renal excretion Watch for early features of memantine toxicity... 

BARBITURATES DIURETICS-CARBONIC ANHYDRASE INHIBITORS Risk of osteomalacia Barbiturates have a small risk of causing osteomalacia this may be T by acetazolamide-induced urinary excretion of calcium Be aware... 

METHENAMINE DIURETICS-CARBONIC ANHYDRASE INHIBITORS 1 efficacy of methenamine Methenamine is only effective at a low pH raising the urinary pH i its effect Avoid co-administration... 

BETA-2 AGONISTS DIURETICS-CARBONIC ANHYDRASE INHIBITORS, LOOP AND THIAZIDES Risk of hypokalaemia Additive effects Monitor blood potassium levels prior to concomitant administration and during therapy. Administer potassium supplements to prevent hypokalaemia... 

Potassium-depleting diuretics Carbonic anhydrase inhibitors Acetazoiamide, Diciofenamide (Dichiorphenamide), Methazolamide... 

These compounds are diuretics, carbonic anhydrase inhibitors. 240... 

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