Diuretic and uricosuric activity in mice

Renal excretion of uric acid consists of three components complete filterability of uric acid in the glomerulus, subsequent tubular reabsorption, and tubular secretion (Gutman and Yu 1961). Pronounced species differences have been described in uric acid metabolism including man. Mice were recommended for primary screening of uricosuric drugs. 

Urine excretion is calculated in ml/kg. Uric acid-, creatinine- and ion-excretions are calculated in mmol/kg and expressed as percent changes versus controls. The changes are evaluated statistically using Student s t-test. 

Some saluretic-diuretic agents, like ethacrynic acid, are inactive in the rat, when given orally. Moreover, uricosuric activity in mice is less reliable than that in primates. 

Hill TWK, Randall PJ (1976) A method for screening diuretic agents in the mouse an investigation of sexual differences. J Pharm Pharmacol 28 552-554 

Sim MF, Hopcroft RH (1976) Effect of various diuretic agents in the mouse. J Pharm Pharmacol 28 609-612 

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