1.2- Dithiolenes degradation studies

A. The Dithiolene Unit as Revealed by Degradation Studies of Molybdopterin / 504... 

Ultimately, the proposed molybdopterin structure in Fig. 5 was verified by protein crystallography that finally revealed the pyran ring whose signature was lost during the degradation studies (42). Conclusive evidence for a dithiolene chelate at the active site came first from the protein crystal structure of a... 

The presence of a pterin-dithiolene (MPT-based) ligand at Mo is the unifying feature of the various molybdenum cofactors (Moco s) and enzymes. " The chemical nature of the pterin-dithiolene ligand was defined by degradative and spectroscopic studies performed by Rajagopalan, Johnson, and coworkers. They proposed the bicyclic structure (4) and... 

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