Dithiocarbazate linker

SOLID-PHASE SYNTHESIS OF RELATED PYRAZOLE COMPOUNDS AND 1,3,4-TRIAZOLES VIA A DITHIOCARBAZATE LINKER... 

The heterocyclic-oriented thioureas have scarcely been reported in the research field of drug-like library construction by solid-phase synthesis, compared to their ureas and simple aromatic thiourea analogues. We have previously described the dithiocarbazate linker 42 and its application to drug-like heterocycle formation." The key intermediate, the... 

Scheme 10.8. Solid-phase synthesis of pyrazoles via a dithiocarbazate linker.

Solid-Phase Synthesis of Pyrazoles via a Dithiocarbazate Linker... 

A general method has been reported for the parallel solid-phase synthesis of 1,2,4-triazole derivatives based on the cyclization of polymer-bound dithiocarbazate 42 (by a two-step sequence from Fmoc-hydrazine) with electrophiles using a similar route to the formation of pyrazole 7." The linker 42 served as a nucleophile for the cyclization reactions with electrophiles such as cyanocarboimidates 46 (R diversity elements) (Scheme 10.11). 

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