Distribution of Alkylglycoside-derivatized AVP In Vivo

Because tissue-specific vectors are aimed at increasing the influx of a drug into the target, assessment of unidirectional transport from the circulating plasma into the target organ is essential. In this context, integration plot analysis is a convenient in vivo method in which a tracer amount of vector is injected intravenously and the plasma (Cp) and tissue (Ct) con- 

In the kidney, the CLuptake includes glomerular filtration as well as renal binding and or uptake from the basal site. Hence, such CLuptake should give the apparent value 

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