Distal region

Pentobarbital withdrawal may involve a distal region of the chromosome 1 in the mouse (Buck et al. 1999), a site that may be identical to that associated with alcohol withdrawal. This finding suggests that common genes may be involved in both ethanol and pentobarbital dependence. 

Figure 9.1 CYP catalytic cycle. The sequential two-electron reduction of CYP and the various transient intermediates were first described in the late 1960s [206], The sequence of events that make up the CYP catalytic cycle is shown. The simplified CYP cycle begins with heme iron in the ferric state. In step (i), the substrate (R—H) binds to the enzyme, somewhere nearthe distal region of the heme group and disrupts the water lattice within the enzymes active site [207], The loss of water elicits a change in the heme iron spin state (from low spin to high spin) [208]. Step (ii) involves the transfers of an electron from NADPH via the accessory flavoprotein NADPH-CYP reductase, with the electron flow going from the reductase prosthetic group FAD to FMN to the CYP enzyme [206,209]. The...

The high thermostability in the thermophilic counterpart was due to amino acid residues located in three distal regions of the protein as shown in Fig. 2. " The introduction of five selected mutations in those regions of Pac-55 caused the protein to attain a similar thermostability to that of the thermophilic protein probably due to a tighter side chain packing and increased total accessible surface area. " ... 

PI3K-C2 y gene locus is mapped to the distal region of mouse chromosome 6 in a region of homology with human chromosome 12p [100]) [100] <32> [103]... 

Exploring distal regions of the A3 adenosine receptor binding site sterically-con-strained iV< -(2-phenylethyl)adenosine derivatives as potent ligands. Bioorg Med Chem 12(9) 2021-2034... 

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