Disseminated intravascular coagulation model

Rhesus monkey model of acute disseminated intravascular coagulation [29,30]... 

Another model that is also used widely in rats and mice is a model of systemic thrombosis or disseminated intravascular coagulation (DIC), which is induced by tissue factor, endotoxin (lipopolysaccharide), or FXa (Herbert et al. 1996 Yamazaki et al. 1994 Sato et al. 1998). After systemic administration of the thrombogenic stimulus, this model can be performed with or without mechanical vena caval stasis. When stasis is used, the major parameter is the thrombus mass, but when stasis is not used, the readouts are... 

Sato K, Kawasaki T, Hisamichi N et al. (1998) Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time. Br J Pharmacol 123 92-96 Yamazaki M, Asakura H, Aoshima K et al. (1994) Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats. Thromb Haemostasis 72 393-396... 

Pyo MK, Lee D-H, Kim D-H, Lee J-H, Moon J-C, Chang KC, Yun-Choi HS. Enantioselective synthesis of (R)-(- -)-and (5)-(—)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation. Bioorg. Med. Chem. Lett. 2008 18(14) 4110-4114. 

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