Disseminated Intravascular Coagulation DIC Model

Another model that is also used widely in rats and mice is a model of systemic thrombosis or disseminated intravascular coagulation (DIC), which is induced by tissue factor, endotoxin (lipopolysaccharide), or FXa (Herbert et al. 1996 Yamazaki et al. 1994 Sato et al. 1998). After systemic administration of the thrombogenic stimulus, this model can be performed with or without mechanical vena caval stasis. When stasis is used, the major parameter is the thrombus mass, but when stasis is not used, the readouts are 

Herbert JM, Bernat A, Dol F et al. (1996) DX 9065A, a novel, synthetic selective and orally active inhibitor of factor Xa in vitro and in vivo studies. J Pharmacol Exp Therapeutics 276 1030-1038 

Sato K, Kawasaki T, Hisamichi N et al. (1998) Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time. Br J Pharmacol 123 92-96 Yamazaki M, Asakura H, Aoshima K et al. (1994) Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats. Thromb Haemostasis 72 393-396 

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