Disseminated intravascular coagulation clinical presentation

In another case of acute systemic allergy to quinine, which mimicked septic shock, with little hemolysis or renal involvement, the patient presented twice with a virtually identical clinical picture sudden fever, rigors, and back pain, followed by hypotension, metabolic acidosis, granulocytopenia, and disseminated intravascular coagulation. On each occasion chnical and laboratory indices recovered spontaneously within 36 hours. A retrospective analysis of the patient s serum showed the presence of neutrophil-specific, quinine-dependent antibodies. 

A detailed description of all the clinical entitites responsible for the development of disseminated intravascular coagulation would, to be sure, provide for an extensive review of morbid anatomy. Only a succinct synthesis of the major clinical and morphological changes are presented here. 

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