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Dispositional antagonism

Dispositional antagonism occurs when one drug alters the pharmacokinetics (absorption, distribution, biotransformation, or excretion) of a second drug so that less of the active compound reaches the target tissue. Tor example, phenobarbital induces the biotransformation of warfarin, reducing its anticoagulant activity... [Pg.43]

Antagonism is a relatively common phenomenon, and antidotal strategies are often based on this type of interaction. Chemical antagonism is a simple interaction between two chemicals in which the formed complex is less toxic. Functional antagonism occurs when two chemicals have opposing actions on physiology, thus their combined effects counteract each other. Kinetic or dispositional antagonism occurs when the absorption, distribution, elimination, or biotransformation of a chemical is altered by... [Pg.515]

Dervieux T, Hancock ML, Pui CH et al. Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia. Clin Pharmacol Ther 2003 73 506-516. [Pg.194]

The disposition, metabolism and effects after acute and chronic dosing of naltrexone were investigated in 4 subjects, showing that narcotic antagonism was related to plasma levels of naltrexone.133... [Pg.25]

See other pages where Dispositional antagonism is mentioned: [Pg.29]    [Pg.20]    [Pg.151]    [Pg.20]    [Pg.30]    [Pg.1119]    [Pg.15]    [Pg.29]    [Pg.20]    [Pg.151]    [Pg.20]    [Pg.30]    [Pg.1119]    [Pg.15]    [Pg.157]    [Pg.114]    [Pg.452]    [Pg.1044]    [Pg.99]    [Pg.165]    [Pg.226]    [Pg.74]   
See also in sourсe #XX -- [ Pg.34 ]

See also in sourсe #XX -- [ Pg.34 ]

See also in sourсe #XX -- [ Pg.34 ]



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