Disorders of Platelet Secretion and Signal Transduction

Congenital Disorders of Platelet Signal Transduction and Secretion 

Koneti Rao, M.D. Departments of Medicine and Pathology Sol Sherry Thrombosis Research Center Temple University School of Medicine 

Hemostasis is a complex sequence of interrelated events involving toe vessel wall, platelets, and the coagulation system. Following injury to the blood vessel, platelets adhere to exposed subendothelium by a process (adhesion) which involves the interaction of a plasma protein, von Willebiand factor (vWF), and a specific protein on the platelet sur ce, glycoprotein Ib (GPIb) (Fig 1). Adhesion is followed by recruitment of additional platelets which form clumps. 

Koneti Rao has made significant contributions to this area of research, specifically on congenital disorders of platelet signal transduction secretion. Dr. Rao has published numerous papers in fliis area. 

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