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Disorders of Platelet Secretion and Signal Transduction

Congenital Disorders of Platelet Signal Transduction and Secretion [Pg.424]

Koneti Rao, M.D. Departments of Medicine and Pathology Sol Sherry Thrombosis Research Center Temple University School of Medicine [Pg.424]

Hemostasis is a complex sequence of interrelated events involving toe vessel wall, platelets, and the coagulation system. Following injury to the blood vessel, platelets adhere to exposed subendothelium by a process (adhesion) which involves the interaction of a plasma protein, von Willebiand factor (vWF), and a specific protein on the platelet sur ce, glycoprotein Ib (GPIb) (Fig 1). Adhesion is followed by recruitment of additional platelets which form clumps. [Pg.424]

Koneti Rao has made significant contributions to this area of research, specifically on congenital disorders of platelet signal transduction secretion. Dr. Rao has published numerous papers in fliis area. [Pg.424]




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