Disintegrant, super crospovidone

Tablets were prepared either with an insoluble (dicalcium phosphate dihydrate), a soluble (6-lactose) or a moderately soluble filler-binder (a-lactose monohydrate). As a disintegrant four different starches (com, rice, potato and tapioca) were used. As a comparison the effect of two super-disintegrants (crospovidone and sodium starch glycolate) was studied. The disintegrants were added at two concentration levels. The compression load was adjusted in order to obtain tablets with comparable initial cmshing strengths.

The four starches used in this study have been proven to be suitable tablet ingredients [19]. Both used super-disintegrants, Primojel (sodium starch glycolate) and Polyplasdone XL (crospovidone), are commonly used as a disintegrant in tablets prepared by direct compression. 

For many years, starch was the disintegrating agent of choice. Recently, however, so-called super disinte-grants have been introduced, which markedly reduce tablet disintegration time. Such substances include croscarmellose, crospovidone, polacrilin potassium, and sodium starch glycolate. ... 

Crospovidone (Polyplasdone XL) swells sparingly in water. Its mechanism of action is based on capillary forces, which allow for fast penetration of water into the tablet. In tablets with a high content of highly soluble compounds, such as anhydrous beta-lactose, it is more effective than both other super-disintegrating agents. 

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